![]() Clinical and metabolic characteristics of these patients were similar to those of the 56 patients who did not have normalized BP. Of the 106 patients who had normalized BMI, 52 also had normalized BP. The former also presented with greater decreases in FPG, FPI, pL, renin and aldosterone levels. ![]() Larger SBP/DBP reductions were observed in 106 patients with normalized BMI (−5/−4.5 mm Hg, P<0.01) compared with the 116 patients who did not become normalized (−3.3/−1.6 mm Hg). In 222 patients who completed the study, a mean weight reduction of 8.1 kg reduced systolic blood pressure (SBP) by 4.2 mm Hg and diastolic blood pressure (DBP) by 3.3 mm Hg ( P<0.05), which was accompanied by a significant decrease in FPI, pL and aldosterone levels ( P<0.05). Body weight, BMI, BP, fasting plasma glucose (FPG), fasting plasma insulin (FPI), leptin (pL), renin and aldosterone levels were evaluated at baseline and after 6 and 12 months. After 6 months, patients with a BW reduction <5% were excluded. Each patient received tailored, low caloric dietary advice. ![]() ![]() We enrolled 376 overweight (body mass index (BMI) ⩾25 and <30 kg m −2) stage 1 hypertensive patients in this prospective 12-month trial. We evaluated the effects of body weight (BW) loss on blood pressure (BP) in overweight non-obese patients with stage 1 hypertension.
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